Last update
5/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin K₂ (as MK-7 [Menaquinone-7])
90 mcg
†
Top Medical Research Studies
9
We designed a multicenter, double-blind, placebo-controlled trial to explore if vitamin K2 can effectively manage nocturnal leg cramps (NLCs).
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
Read More
Most Useful Reviews
7.5
Improved leg circulation
1 people found this helpful
Since taking this once a day for several months, my ankles are not as blue, and my legs do not tire as easily. I have serious varicose veins and am aware it thickens the blood slightly if you take warfarin, which I used to take. I switched to apixaban, which spares some vitamin K, and I’ve noticed quicker hair and nail growth, too.
Read More
9
Leg pain relief
Joints often ache, especially in the weather, but after taking vitamin K2, my legs stopped hurting!
Read More
9
Awaiting results
I ordered these pills on recommendation for my leg issues. I have not used them yet, but I read that this preparation contains harmless components.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We designed a multicenter, double-blind, placebo-controlled trial to explore if vitamin K2 can effectively manage nocturnal leg cramps (NLCs).
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved leg circulation
1 people found this helpful
Since taking this once a day for several months, my ankles are not as blue, and my legs do not tire as easily. I have serious varicose veins and am aware it thickens the blood slightly if you take warfarin, which I used to take. I switched to apixaban, which spares some vitamin K, and I’ve noticed quicker hair and nail growth, too.
Read More
9
Leg pain relief
Joints often ache, especially in the weather, but after taking vitamin K2, my legs stopped hurting!
Read More
9
Awaiting results
I ordered these pills on recommendation for my leg issues. I have not used them yet, but I read that this preparation contains harmless components.
Read More
Frequently Asked Questions
7.5
Improved leg circulation
1 people found this helpful
Since taking this once a day for several months, my ankles are not as blue, and my legs do not tire as easily. I have serious varicose veins and am aware it thickens the blood slightly if you take warfarin, which I used to take. I switched to apixaban, which spares some vitamin K, and I’ve noticed quicker hair and nail growth, too.
9
Leg pain relief
Joints often ache, especially in the weather, but after taking vitamin K2, my legs stopped hurting!
9
We designed a multicenter, double-blind, placebo-controlled trial to explore if vitamin K2 can effectively manage nocturnal leg cramps (NLCs).
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
Conducted in China with older adults experiencing regular cramps, participants were randomly assigned to receive either vitamin K2 or a placebo for 8 weeks. Remarkably, our findings demonstrated that vitamin K2 significantly reduced the frequency, duration, and intensity of NLCs, making it a promising option for those suffering from this discomfort.
Notably, the treatment showed good safety profiles, reinforcing its potential utility in managing leg cramps.
References
- Tan J, Zhu R, Li Y, Wang L, Liao S, et al. Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2024;184:1443. 10.1001/jamainternmed.2024.5726
